South Africa face England at Ellis Park in the opening round of the Nations Championship, with the Springboks forced into significant late changes to their matchday 23.

Siya Kolisi and Eben Etzebeth have both withdrawn, bringing Paul de Villiers and Cameron Hanekom into the starting XV. Pieter-Steph du Toit shifts to the second row and takes over the captaincy.

England have also been hit by a late change, with George Furbank ruled out through illness. Marcus Smith moves into the starting side, while Henry Slade is added to the replacements bench.