Aimee Barrett-Theron, the world's most capped female referee with 52 Tests, has stood down from officiating with immediate effect after being diagnosed with breast cancer.

The 39-year-old Cape Town-based referee, who last officiated in June when she took charge of the South Africa 'A' vs Zimbabwe match at the Nelson Mandela Bay Stadium, has informed both SA Rugby and World Rugby that she will be unavailable for the foreseeable future.

Barrett-Theron confirmed the diagnosis publicly, stressing that her condition is treatable. "The good news is that it's treatable, and I'm working with an incredible team of specialists who are fully aligned with the goal of getting me healthy and back on the field in a few months' time," she said.

She also used the announcement to urge others toward self-examination: "I found this through a self-check, so please let this be your reminder: check yourself, listen to your body, and don't delay getting anything unusual looked at."

Barrett-Theron made history as the first woman to referee a men's match in South Africa and previously represented the country in both XVs and sevens. SARU president Mark Alexander described her as "a resolute and focused trail-blazer" and expressed confidence she would meet the challenge of recovery with the same determination that defined her rise through the refereeing ranks.